解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::[This retracts the article DOI: 10.17179/excli2015-642.]. ...
journal_title:EXCLI journal
pub_type: 杂志文章,撤回出版物
doi:10.17179/excli2016-570
更新日期:2016-09-19 00:00:00
abstract::Oxidative stress is the common underlying mechanism of damage in ischemic stroke. Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene derivatives on brain infarction and oxidative/nitrosative stress in a rat model of ischemic stroke. The experiment was performed by four groups...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-309
更新日期:2016-06-20 00:00:00
abstract::L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term administration may cause immunological responses, so screening f...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-146
更新日期:2016-04-18 00:00:00
abstract::Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a h...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2014-585
更新日期:2016-02-15 00:00:00
abstract::Phoenix sylvestris (Arecaceae family) known as Indian Date Palm has been identified as a component of traditional medicine against various ailments. The present study was focused on phytochemical screening of crude hexane, dichloromethane and methanol leaf extracts. The crude extracts showed the presence of alkaloids,...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-689
更新日期:2016-02-05 00:00:00
abstract::One of the most fundamental operations in biological sequence analysis is multiple sequence alignment (MSA). The basic of multiple sequence alignment problems is to determine the most biologically plausible alignments of protein or DNA sequences. In this paper, an alignment method using genetic algorithm for multiple ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-302
更新日期:2015-12-15 00:00:00
abstract::Spontaneous eye-blinks occur much more often than it would be necessary to maintain the tear film on the eyes. Various factors like cognitive demand, task engagement, or fatigue are influencing spontaneous blink rate. During cognitive information processing there is evidence that blinks occur preferably at moments tha...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-696
更新日期:2015-11-27 00:00:00
abstract::The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-469
更新日期:2015-09-28 00:00:00
abstract::The present study is conducted to determine the potential mechanisms of Boron compounds, boric acid (BA) and borax (BX), on genotoxicity of zebrafish Danio rerio for 24, 48, 72 and 96-hours acute exposure (level:1, 4, 16, 64 mg/l BA and BX) in semi-static bioassay experiment. For that purpose, peripheral erythrocytes ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-404
更新日期:2015-07-30 00:00:00
abstract::This study aims to develop two alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT) and to determine their equivalency and practice effect. Ninety healthy volunteers were subjected to the following neuropsychological tests at baseline, and at one month interval according to their assigned group; ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-280
更新日期:2015-07-07 00:00:00
abstract::Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-245
更新日期:2015-05-18 00:00:00
abstract::Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 pat...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2014-671
更新日期:2015-04-10 00:00:00
abstract::Salmonella enterica serovar Typhi (S. Typhi) is a human restricted pathogen. It biosynthesizes a virulence capsular polysaccharide named as Vi antigen. S. Typhi regulates expression of genes involved in the biosynthesis of Vi antigen in response to osmolarity. Beside Vi-positive isolates, Vi-negative (acapsulated) iso...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2014-674
更新日期:2015-02-09 00:00:00
abstract::The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2014-576
更新日期:2015-01-06 00:00:00
abstract::The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2013-609
更新日期:2015-01-06 00:00:00
abstract::This review will concentrate on the clinical pharmacology, in particular pharmacodynamic data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬tiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. A summary of their acute pharmaco...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-10-13 00:00:00
abstract::Doxorubicin (DOX) is an excellent antineoplastic agent used for the treatment of hematological and solid malignancies. The aqueous extract of Bombyx mori (BMAE) contains amino acids and some flavonoids with obvious cardioprotective effect. The aim of this study was to investigate the possible protective effect of BMAE...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-09-05 00:00:00
abstract::To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our prev...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-08-20 00:00:00
abstract::The essential oil obtained from leaves of Melissa officinalis L. (Family of Lamiaceae) growing in Algeria, was investigated for its chemical composition and in vitro antimicrobial activity. The chemical composition was determined by hydrodistillation and analyzed by GC/MS and GC-FID. Sixty-three compounds were identif...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-07-17 00:00:00
abstract::Presently, functional foods and nutraceuticals are gaining immense importance in the prevention of various maladies through dietary regimen module. Consumption of fruits and vegetables based diet has pursuit a range of bioactive components, especially phytochemicals targeting life threatening ailments. In this context...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-06-03 00:00:00
abstract::The chemical composition of the essential oils of different Allium nigrum L. organs and the antibacterial activity were evaluated. The study is particularly interesting because hitherto there are no reports on the antibacterial screening of this species with specific chemical composition. Therefore, essential oils fro...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-05-13 00:00:00
abstract::A series of phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides (TTa-TTg) were synthesized by the ring closure reaction of phenyl-1-(thiophen-2-yl) prop-2-en-1-ones with thiosemicarbazide in alcoholic basic medium. All the final derivatives were evaluated for their antidepressant and neurotoxicity scre...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-04-29 00:00:00
abstract::Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulatio...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-20 00:00:00
abstract::The aim of this study was to evaluate the effect of acute and chronic physical and psychological stressors on the induction of oxidative stress in male rat liver. Male Wistar rats were randomly divided into 3 groups as following: control, physical and psychological stress groups. Stress was induced by communication bo...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-02-24 00:00:00
abstract::Morphological identification is a widespread procedure to assess the presence of apoptosis by visual inspection of the morphological characteristics or the fluorescence images. The procedure is lengthy and results are observer dependent. A quantitative automatic analysis is objective and would greatly help the routine...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-01-29 00:00:00
abstract::Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-11-11 00:00:00
abstract::DNA and chromosomal damage in peripheral blood leukocytes of patients with coronary artery disease (CAD) were investigated by using the single cell gel electrophoresis assay /comet and cytokinesis- block micronucleus (CBMN) assays, respectively. The case-control study comprised patients with CAD (n = 46; average age 5...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-10-08 00:00:00
abstract::Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in W...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-09-24 00:00:00
abstract::Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macrom...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-09-23 00:00:00
abstract::Patients with diabetes tend to have an increased risk of osteoporosis that may be related to hyperglycemia. In vitro evidence has shown that high glucose can affect the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). Tissue regeneration depends mainly on MSCs. However, the exact mechanis...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-06-27 00:00:00
abstract:INTRODUCTION:Hypovitaminosis D is reported to be associated with several medical complications. Recent studies have reported a high worldwide prevalence of Vitamin D deficiency in the general population (up to 80 %). This is even higher in patients with chronic kidney disease (CKD) and increases with advancing stages o...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-06-11 00:00:00
abstract::Experimentally-induced total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR) leads to the emergence of cognitive impairments. This is hypothesized to result from a consequent neuroinflammation which may also hasten the neurodegenerative processes. Neuroinflammatory markers such as tumor necrosis f...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-04-14 00:00:00
abstract::There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We inves...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-03-14 00:00:00
abstract::Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid that is found in plants and herbal products. It is one of the chemopreventive agents, which can suppress cancer cell proliferation and induce apoptosis. UA possesses various biological activities including anticancer, anti-inflammatory, anti-oxidative and...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-02-08 00:00:00
abstract::Numerous studies have demonstrated the robustness of the framing effect in a variety of contexts, especially in medical decision making. Unfortunately, research is still inconsistent as to how so many variables impact framing effects in medical decision making. Additionally, much attention should be paid to the framin...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-01-18 00:00:00
abstract::Five Calligonum species endemic to the Tarim Basin - C. roborowskii, C. kuerlese, C. juoqiangense,C. yengisaricum, and C. taklimakanense - were compared using 14 morphological characteristics and nrDNA ITS and cpDNA trnL-F molecular data. Intraspecific and interspecific morphological variation was uncovered, with vari...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-12-20 00:00:00
abstract::The effect of leaf essential oil of Hoslundia opposita (Vahl) on the haematological parameters of alloxan-induced diabetic rats was investigated. Forty-eight albino rats (Rattus norvegicus), of average weight 132.5 g, were randomly selected into normal and diabetic groups, each with four sub-groups. The rats were trea...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-09-25 00:00:00
abstract::Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-09-07 00:00:00
abstract::Corn cob is a major component of agricultural and domestic waste in many parts of the world. It is composed mainly of cellulose which can be converted to energy in form of bioethanol as an efficient and effective means of waste management. Production of cellulolytic enzymes were induced in the fungi Aspergillus niger ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-08-15 00:00:00
abstract::From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-07-05 00:00:00